In contrast, a study cohort with a smaller sample of patients with sporadic BCC found PTCH1 mutations in 72% of the cases, along with other genes such as CSMD1 (63%), TERT promoter (58%), DPH3 promoter (49%), TP53 (46%), NOTCH1 (44%), DPP10 (35%) [33], representing the wide variability and cellular mechanisms involved in BCC pathogenesis. The gene discussed is NOTCH1; the disease is skin basal cell carcinoma.