Verkouteren et al. [31] described that about 85% of sporadic BCC could display variants in genes implicated in Hedgehog signaling (SHH, SMO, GLI1, GLI2, GL3), in which loss of heterozygosity (LOH) is a common trait, although the profile of genetic variants in BCC is complex and variable. Here, SHH is linked to skin basal cell carcinoma.