The vast majority of previous studies have used ML methods for the binary classification of brain tumors, particularly to differentiate between two subgroups of gliomas, e.g., low-grade vs. high-grade [68,69,70] or isocitrate dehydrogenase (IDH) wild-type vs. mutated [71,72,73,74], or to differentiate between GBMs and brain metastases [75,76,77,78,79]. This evidence concerns the gene IDH3A and brain neoplasm.