LPA has been shown to drive ovarian cancer cell migration and invasion [235], activate NF-kB [236] and AP-1 transcription factors [237], increase cyclooxygenase 2 production, and induce metabolic reprogramming of ovarian cancer cells inducing a glycolytic shift via hypoxia-inducible factor 1 activation [233]. Here, NFKB1 is linked to ovarian carcinoma.