HA-labeled PLGA NPs loaded with paclitaxel and focal adhesion kinase (FAK) siRNA were prepared by Byeon et al. The HA-labelled NPs exhibited higher binding efficiencies for CD44-positive tumor cells, resulting in elevated cytotoxicity and apoptosis in drug-resistant tumor cells, and significantly inhibited tumor growth in patient-derived xenograft models compared to the free drug [155]. This evidence concerns the gene CD44 and neoplasm.