For example, PAR-2 (F2RL1) is overexpressed in some ovarian cancer tissues mainly inducing cell migration, and PAR-1 (F2R) has been found to be abundant in invasive carcinomas, but not in the healthy ovarian epithelium, driving FAK signaling and promoting cancer malignancy [262,263]. The gene discussed is F2R; the disease is invasive carcinoma.