This score integrates the ECOG performance status, tumor burden (including portal invasion status and hepatic spread), and an evaluation of the underlying liver function that should be estimated beyond the Child–Pugh score using the Model for End-Stage Liver Disease score (MELD) in decompensated cirrhosis or alpha-fetoprotein (aFP) concentration and albumin-bilirubin score (ALBI) in compensated liver disease [4]. This evidence concerns the gene ALB and neoplasm.