The most commonly altered genes in this cohort were VHL (n = 34, 56.7%), PBRM1 (n = 18, 30.0%), SETD2 (n = 16, 26.7%), and BAP1 (n = 12, 20.0%), which were generally similar to those previously reported for ccRCC (Figure 1A) [4,9]. The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.