PPARGC1A and breast cancer: To investigate how these non-coding variants affect PPARGC1A expression, we compared PPARGC1A expression between the carriers of non-coding variants and the non-carriers using PCAWG RNA-seq data [33] and observed a trend of lower expression in the carriers (p = 0.09 and 0.44 for ovarian cancer and breast cancer, respectively, Figure S2).