GPX4 and non-small cell lung carcinoma: On the other hand, NEAT1 inhibits erastin-induced ferroptosis by not only increasing GPX4 and SLC7A11-mediated antioxidative pathways but also decreasing ACSL4-mediated lipid peroxidation, which may confer the resistance to erastin in non-small cell lung cancer (NSCLC) cells [84].