IL6 and neoplasm: Although TAMs can also be broadly divided into M1 and M2 phenotypes [26,27], it is believed that most resident TAMs exhibit a M2-like phenotype induced by chemokines, tumor-derived cytokines, and proteases, such as IL-4, IL-6, IL-10, TGF-β1, and polyethylene glycol (PEG) [28,29].