Previous studies [6,7] have shown that IgG and IgA antibodies in patients with IgG/IgA pemphigus could target Dsg1, Dsg3, and/or desmocollin 1 (Dsc1)–Dsc3 to a different extent, which may account for the mixed clinical presentations of the disease. The gene discussed is DSC1; the disease is pemphigus.