Previous studies have shown that the transfer of fecal microbiota collected from lean rats into NASH rats fed a high-fat glucose/fructose diet (HFGFD) restored the sensitivity to insulin of the hepatic protein kinase B (Akt)-dependent endothelial nitric oxide synthase (eNOS) signaling pathway, and thereby led to an improvement in intrahepatic vascular resistance (IHVR) and portal pressure (PP) [11]. Here, NOS3 is linked to metabolic dysfunction-associated steatohepatitis.