In particular, this study carried out in women with hyperandrogenism, oligomenorrhea and female sexual dysfunction reports that an increase in the amount of sex-hormone-binding globulin (SHBG) is directly proportional to a pathological situation of NAFLD; in fact, an SHBG level of 33.4 nmol/L was recognized as the best threshold, with a sensitivity of 73.3% and a specificity of 70.7%, making this hormone a candidate for the monitoring of the dangerousness of having NAFLD in these types of patients, who may also not have metabolic syndrome [27]. The gene discussed is SHBG; the disease is metabolic syndrome.