The components of the pathway involved in the clearance of LDL from blood, such as LDL receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) responsible for the enhanced degradation of LDLR (also related to increased damage of mitochondrial DNA, and certain types of cancer), should, therefore, be considered as factors affecting atherogenicity [13,14,15]. The gene discussed is LDLR; the disease is cancer.