Previous studies reported adipocyte hypertrophy in lipedema hypodermal adipose tissue by the measurement of adipocyte size in histological stainings [17,18,25] and increased expression of typical adipogenic genes, such as PPARγ, adiponectin and leptin, in differentiated ASC cultures derived from the SVF of healthy and lipedema subjects [34]. Here, ADIPOQ is linked to Lipedema.