S1PR3 and neoplasm: Unfortunately, we could not directly investigate the chemosensitizing effects of RNA interference-mediated silencing of VCAN, S1PR3, and PDGFRB, and PRKCG because KD of these genes alone induced a dramatic growth inhibition in UMUC-3-GEMr cells, supporting their respective roles in OGT-mediated tumor aggressiveness in chemoresistant UCB.