Moreover, OGT silencing retarded the in vivo tumor growth capability of UMUC-3-GEMr cells (Figure 4C) through the suppression of cell proliferation (Ki-67) and induction of apoptosis (caspase-3), even without the addition of GEM (Figure 4D), which further suggests the additional tumor-promoting effects of OGT in chemoresistant UCB. This evidence concerns the gene MKI67 and neoplasm.