Interestingly, a single nucleotide polymorphism associated with the reduced expression of the LMTK1 gene (AATK1) has been identified as an FTD risk factor within an Italian cohort [205], suggesting that abnormal GAP regulation may be a contributory factor in tau pathology, as well as potentially in the amyloidogenic processing of APP. Here, MAPT is linked to frontotemporal dementia.