RAB1A and Parkinson disease: For example, overexpression of the yeast Rab1 homolog Ypt1p rescues dopaminergic neuron loss caused by α-synuclein in animal models of Parkinson’s disease (PD) [17], whilst overexpression of Rab1A in rodent models of PD was found to prevent pathological Golgi fragmentation and rescue motor deficits [18].