Importantly, when FGFR2 was knocked down by small interfering RNA and/or inhibited with infigratinib, it led to decreased expression of RAD51 after doxorubicin exposure in imatinib-resistant GIST cells suggesting the attenuation of DNA repair mechanisms, providing the potential mechanism of GIST sensitization to DNA damaging agents [11,33]. Here, FGFR2 is linked to gastrointestinal stromal tumor.