Importantly, when FGFR2 was knocked down by small interfering RNA and/or inhibited with infigratinib, it led to decreased expression of RAD51 after doxorubicin exposure in imatinib-resistant GIST cells suggesting the attenuation of DNA repair mechanisms, providing the potential mechanism of GIST sensitization to DNA damaging agents [11,33]. This evidence concerns the gene RAD51 and gastrointestinal stromal tumor.