A bioinformatic analysis of the genes and biochemical pathways correlated with CTNNB1 (β-Catenin) expression performed on a database of CRC-affected patients showed that it is positively correlated to several genes involved in biological processes, which include mitotic cell cycle process, cell migration, epithelial-to-mesenchymal transition (EMT), regulation of gene expression; in contrast, CTNNB1 expression negatively correlated with genes exerting a tumor suppressive role and genes involved in the autophagy-lysosomal pathway, particularly ATG4D. This evidence concerns the gene ATG4D and neoplasm.