The genetic silencing of the autophagy gene ATG7 restores the level of β-Catenin and abrogates the cell cycle arrest in CRC cells exposed to butyrate, confirming that, in CRC cells bearing mutations in the machinery for the degradation of β-Catenin, this probiotic metabolite still elicits anti-proliferative activity, by activating an alternative degradation of the downstream effector of the WNT pathway. This evidence concerns the gene ATG7 and colorectal carcinoma.