Thus, GAMs under the influence of GBM cells may release both immune-suppressive factors, such as transforming growth factor β1 (TGF-β1) and interleukin 10 (IL-10), and also pro-inflammatory factors including interleukin 1 (IL-1) and tumor necrosis factor (TNF) [41]. The gene discussed is TNF; the disease is glioblastoma.