Analysis of the TCGA database comparing the methylation status of CpG sites in the ODZ1 gene in GBM tissue and normal brain revealed two CpG sites hypomethylated in GBM and only one of these sites (cg24761295), closed to the transcription start site, was confirmed to be hypomethylated in a prospective study with tumor specimens from 10 GBM patients [77]. This evidence concerns the gene TENM1 and glioblastoma.