Interestingly, a comparative analysis of the SOD1-A4V, C9ORF72, TDP43-Q343R, and sporadic ALS-induced motor neuron lines revealed glycerophospholipid metabolism alterations, and most specifically, the activation of the arachidonic acid (AA) pathway, as the common metabolic signature [82]. Here, TARDBP is linked to amyotrophic lateral sclerosis.