In general, not many differential lipid species were detected in the frontal cortex of these TDP43 proteinopathies; just 63 out of the total of 1119 lipid species identified were significantly different, and most of them showed decreased levels versus the controls; mainly, glycerophospholipids (phosphocholine PC; phosphoethanolamine PE) and sphingomyelin SM, which might reflect the neurodegenerative process in the brain. The gene discussed is TARDBP; the disease is proteostasis deficiencies.