The main differences found among the different forms of TDP43 proteinopathies in the frontal cortex were in TG levels (mostly 18:1 oleic acid), which was higher in the ALS group compared to the FTLD-TDP group, and the increased levels of cholesterol ester CE (20:1) in the c9FTLD group. The gene discussed is TARDBP; the disease is proteostasis deficiencies.