SOD1 and amyotrophic lateral sclerosis: In addition, genes involved in the catabolism of glycosphingolipids were found to be upregulated, with a consequent increase in ceramide synthesis [64], in a meta-analysis of transcriptomic studies of the spinal cord of SOD1 mice spinal cords, which is consistent with the accumulation of ceramides observed in the spinal cord of ALS patients [60].