DKC1 and colon carcinoma: Recently, to study the telomerase-independent functions of human dyskerin, we developed an inducible cellular silencing system (pLKO-Tet-On-shDKC1 silencing vector) capable of depleting dyskerin in human colon carcinoma (RKO) cells upon the addition of tetracycline or doxycycline in culture media [9].