Missense and nonsense mutations in the SCN1A gene, encoding the α-subunit of the NaV1.1 VGSC, are associated in a wide range of epileptic disorders in which FS are involved, such as Dravet syndrome [4], generalized epilepsy with febrile seizures plus (GEFS+) [5], simple FS [6] and MTLE with HS [7]. This evidence concerns the gene SCN1A and generalized epilepsy.