AIF1 and Parkinson disease: Excessive ROS formation has been listed as a major mechanism related to Parkinson’s disease (PD) and can trigger many types of damage, including neuroinflammation [11,12], characterized by the presence of activated microglia and reactive astrocytes in the brain parenchyma (indicated by the expression of Iba-1 and GFAP, respectively) and proinflammatory cytokines release.