Zn indicators can measure the intracellular distribution of Zn2+ [10], and it was revealed that, upon moderate exposure, Zn2+ is transferred by TRPM7 (transient receptor potential cation channel subfamily M member 7) into specific vesicles that release Zn2+ in response to oxidative stress [9] or in response to TRPM7 agonists, promoting melanoma cell death by inhibiting autophagy [13,90]. This evidence concerns the gene TRPM7 and melanoma.