CD274 and neoplasm: Triuzli et al., using gene expression and immunohistochemistry, stratified HER-positive IDCs into trastuzumab-resistant and trastuzumab-sensitive tumours, and showed that the latter had significantly higher levels of CC and CXCL chemokines (involved in the recruitment of monocytes and migration of T and B cells, respectively), a denser infiltration of CD8+ and CD68+ cells, and higher levels of PD-L1 and PD-L2 [86].