Based on a seminal study by Perou et al., four main molecular subtypes of BC, related to the expression of the estrogen receptor (ER), the progesterone receptor (PR), and HER2 (ER/PR/HER2 status), have been distinguished: Luminal A, Luminal B, HER2-positive, and Triple Negative (TN) [42]. Here, ESR1 is linked to breast cancer.