In the field of insulin secretion and beta-cell function, mathematical modelling may have direct implications for anti-diabetes therapy, especially in the consideration that, currently, several pharmacological agents are available that can stimulate insulin secretion, such as the dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists and sulphonylureas. The gene discussed is INS; the disease is diabetes mellitus.