In a case-control study, 216 adrenocortical tumors, negative for pathogenic variants in PRKAR1A, GNAS, and PDE11A, in unrelated patients and 192 controls were screened for genetic variations in PDE8B; six different variants in seven patients were identified (one PPNAD, one ACC, two PBMAH, two secreting-ACA, one non-secreting ACA) [41]. The gene discussed is PDE8B; the disease is adrenal cortex neoplasm.