In a cohort of patients with 44 sporadic adrenocortical tumors (29 adenomas and 15 cancers), losses in 17q22-24 were found in 23% of the adenomas and 53% of cancers, while inactivating variants in the PRKAR1A gene were identified in three tumors [34]. The gene discussed is PRKAR1A; the disease is adrenal cortex neoplasm.