Nuclear factor kappa-light-chain enhancer of activated B cells (NFKB), a family of transcription factors including NFKB1 (p50–p65, canonical) and NFKB2 (p52-RelB, non-canonical), is known to regulate the expression of different tumor-promoting cytokines including MIF and their receptors [34,35,36]. This evidence concerns the gene RELB and neoplasm.