Under the condition without treatment (No Tx), MV4-11 was found to release different cytokines in their supernatant; however, one dose of GILT-treatment significantly reduced the release of a variety of cytokines, such as Osteopontin (Figure 1A), a protein closely associated with adverse prognosis in AML patients [20]. The gene discussed is SPP1; the disease is acute myeloid leukemia.