CXCL8 and acute myeloid leukemia: Our current findings showing MIF’s expression in AML cell lines and primary blasts (Figure 1) and MIF-induced expressions of CXCL1/5/8 and CXCR2 in MV4-11 cells in vitro (Figure 2) are consistent with a previous report that primary AML blasts constitutively express MIF, stimulating bone marrow mesenchymal cells to release the CXCR2 ligand CXCL8 (IL-8) to sustain blasts’ survival [42].