NFKB1 and inflammatory bowel disease: The metabolites of Faecalibacterium prausnitzii can alter the pro-inflammatory response due to its protective effect on the gut barrier as well as the inhibition of NF-κB activation [187], thus other inflammatory diseases including ankylosing spondylitis and IBD also show a decreased in abundance of Faecalibacterium prausnitzii [124,183].