Janus kinases (JAKs) signaling, nuclear factor kappa (NF-κB) signaling, transforming growth factor beta (TGF-β), interleukin 23–interleukin 17 (IL-23-IL-17) signaling, T cell regulation, disruption of epithelial barrier function, autophagy, and dysregulated apoptosis are all involved in psoriasis pathogenesis [52,53,54]. The gene discussed is IL17A; the disease is psoriasis.