Tumor angiogenesis is dependent on a highly complex program of growth factor signaling (i.e., VEGF, transforming growth factor (TGF), alkaline fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF)), endothelial cell (EC) proliferation, extracellular matrix (ECM) remodeling, and stromal cell interactions. This evidence concerns the gene VEGFA and neoplasm.