AKT1 and chondrosarcoma: Similarly, in chondrosarcoma studies, resistin and VEGF-A expression were positively correlated, resistin and VEGF-A were negatively correlated with miR-16-5p, and resistin inhibited miR-16-5p expression through PI3K/Akt signaling to promote VEGF-A expression and angiogenesis [37,38].