TNF and nervous system disorder: Interestingly, a direct link between neuroinflammation and ECM remodeling/damage has been described during spinal cord injury [43], angiogenesis [44], and immune cell differentiation and migration [45], as well as microglial activation [46] and the pathogenesis of various neurological diseases [47,48,49], further indicating that our TNFα- and IL-1β- stimulated hCSs may well represent a valuable model of neuroinflammation.