Regardless of insulin resistance, the two groups of women with morbid obesity showed upregulation of LYPD8 and downregulation of a greater number of genes, such as REG1B, GKN2, LPL, PNLIPRP2, FKBP5, and CD86, that are related to responses to bacterial stimuli and antimicrobial activity. Here, REG1B is linked to morbid obesity.