GKN2 and Insulin resistance: Regardless of insulin resistance, the two groups of women with morbid obesity showed upregulation of LYPD8 and downregulation of a greater number of genes, such as REG1B, GKN2, LPL, PNLIPRP2, FKBP5, and CD86, that are related to responses to bacterial stimuli and antimicrobial activity.