In the medulla, after the initial massive skin infection with S. epidermidis, the surface area of T lymphocytes (CD43+), T helper lymphocytes (CD4+), T cytotoxic lymphocytes (CD8+), macrophages and monocytes (CD68+), granulocytes (HiS48+), stem cells, immature B cells and thymocytes (CD90+), activated antigen-presenting cells (MHC class II+), and CD54+ dendritic, endothelial, and ICAM-1+ cells (CD54+) significantly increased on day 8 compared with controls obtaining 0.9% NaCl. The gene discussed is SPN; the disease is skin infection.