NR1H4 and early-onset autosomal dominant Alzheimer disease: The top 15 up- and downregulated DEGs are listed in the tables shown in Figure 2B. Using the 158 downregulated genes, IPA identified FXR/RXR activation, LXR/RXR activation, atherosclerosis signaling, neuroprotective role of THOP1 in Alzheimer disease, and PXR/RXR activation pathways as the top five significantly downregulated and enriched canonical pathways (Figure 2C, −log (p-value) > 1.3).