Among the top regulated canonical pathways, the farnesoid X receptor/retinoid X receptor (FXR/RXR) and the liver X receptor/retinoid X receptor (LXR/RXR) activation pathways were downregulated in StCs but upregulated after Ex-4 treatment, indicating that these pathways may play a pivotal role in the Ex-4-induced steatosis improvement that we observe in our model. This evidence concerns the gene NR1H4 and steatosis.