The chronization of asthma and development of lung fibrosis was shown to either not affect observed asthma-driven upregulation of the genes, as in the case of Col1a1, Col4a1, and Col4a2, or downregulate the expression of Thbs2 and Tyrobp almost to the level of healthy control (Figure 6C). Here, COL4A1 is linked to asthma.