The expression levels of key genes associated with both acute asthma and pulmonary fibrosis development (Fn1, Igf1, Ccl2, C3, Timp1, Cxcl12, Ccl4, Ccr2, Spp1, C3ar1, Cat, Cyp2e1, Muc5ac, and Muc5b), revealed by bioinformatics analysis, were evaluated in the lung tissue of OVA-challenged mice 24 h (asthmatic lungs) and 4 weeks (fibrotic lungs) after last OVA exposure by TaqMan-based qRT-PCR. Here, C3 is linked to pulmonary fibrosis.