SPP1 and asthma: Given the high association of genes listed in Figure 3F with both asthma and pulmonary fibrosis, the top-10 asthma-related genes the most interconnected with pulmonary fibrotic regulome (Fn1, Igf1, Ccl2, C3, Timp1, Cxcl12, Ccl4, Ccr2, Spp1, C3ar1); Cat, playing an important role in fibrosis of various organs [63,64,65]; as well as Cyp2e1 and Muc5ac/Muc5b, more specific for liver and lung fibrosis, respectively, were selected for further validation in a murine model of OVA-induced asthma.