CYP2E1 and renal fibrosis: It was found that Ccl2, Ccr2, Cxcl12, Timp1, Igf1, Spp1, and Cat were interconnected with fibrosis of all three organs and, therefore, can be considered as probable pan-fibrotic markers; Ccl4/Thbs were associated with fibrotic changes in both liver and kidney; and Muc5b/Muc5ac/Grp, Cyp2e1, and C3 were more specific for pulmonary, hepatic, and renal fibrosis, respectively (Figure 3E).