TIMP1 and pulmonary fibrosis: Metalloproteinase inhibitor TIMP1 was found to be involved in the maintenance of a balance between proteases and anti-proteases in lungs, the impairment of which leads to idiopathic pulmonary fibrosis development [94], and regulates the proliferation of fibroblasts by direct interaction with CD63 and integrin β1 exposed on their surface [95].