Thus, performed qRT-PCR analysis and IHC studies, on the one hand, clearly demonstrate the credibility of performed bioinformatics analysis, and, on the other hand, show that 9 of 14 evaluated asthma-specific key nodes are significantly up- (Fn1, Igf1, Ccl2, C3, Timp1, Muc5b, Muc5ac) or downregulated (Cat, Cyp2e1) not only in asthmatic, but also in fibrotic lung tissues, indicating their probable associations with early fibrotic changes in the respiratory tract already at the stage of asthma-driven inflammation. This evidence concerns the gene C3 and asthma.