Interestingly, 6 of the 10 revealed asthma-specific hub genes (Ccl6, Ccl9, Ccl12, Timp1, Muc5ac, Cyp2e1) were involved in rodent inflammatome, a gene signature identified previously by Wang et al. in 11 independent rodent inflammatory disease models [61], clearly showing their key regulatory function in acute inflammation (Figure 2E). This evidence concerns the gene TIMP1 and asthma.