SPP1 and pulmonary fibrosis: Further overlapping of these genes with the core asthma-related gene network (Figure 6A, bottom panel) demonstrated that 11 asthma-annotated genes, including three key nodes (Ccl6, Ccl9, Timp1) (Figure 2E) and five genes displaying high interconnections with DisGeNET-retrieved lung fibrosis regulome (Igf1, Timp1, Spp1, Tnc, Mmp12) (Figure 3F), were associated with the development of bleomycin-induced fibrotic changes in lungs (Figure 6A), which indicates a possible universality of the pathways regulating pulmonary fibrosis of different etiologies.