ADRA2A and asthma: In the first step, we analyzed cDNA microarray datasets connected with acute allergic airway inflammation and revealed top-10 core genes (Ccl6, Ccl9, Ccl12, Timp1, Muc5ac, F5, Cyp2e1, Adra2a, Ear1, Tk1) characterized by (a) nodal disposition within asthma-related gene networks, (b) association with the well-known processes involved in the regulation of asthma, and (c) close connection both with “asthma” and “pulmonary fibrosis” terms in the scientific texts (Figure 2).