The comparison of gene markers of asthma and asthma-associated pulmonary fibrosis with key genes of allergy-independent bleomycin-induced fibrosis demonstrated low interconnection of asthma-related DEGs with bleomycin-perturbed regulome in murine lungs—only 11 genes were identified as common for both asthma/post-asthmatic fibrosis and bleomycin-induced fibrosis (Figure 6A, lower Venn diagram), among which three genes (Igf1, Spp1, Timp1) displayed the most obvious association with fibrotic process in lungs. Here, SPP1 is linked to allergic disease.