The most influential nodes (Fn1, Igf1, Ccl2, C3, Timp1, Cxcl12, Ccl4, Ccr2, Spp1, C3ar1, Cat, Cyp2e1, Muc5ac, Muc5b) were selected for further validation in the OVA-induced asthma and post-asthmatic fibrosis murine model (Figure 3F). The gene discussed is SPP1; the disease is asthma.