Because necroptosis in experimental atherosclerosis has so far only been studied in classical mouse models such as the ApoE−/− or LDLr−/− mouse [3,4,5,7,8,9,24], we analyzed the expression of necroptosis proteins in plaques of ApoE−/− and ApoE−/− Fbn1C1039G+/− mice. This evidence concerns the gene APOE and atherosclerosis.