RIPK1 and atherosclerosis: Despite recent findings showing that RIPK1 is a central driver of inflammation in atherosclerosis [4,7,8], the role of RIPK1 in the progression and destabilization of atherosclerotic plaques is not straightforward and is complicated by its dual nature, namely a scaffolding function (regulating pro-survival signaling and inflammatory gene expression) versus kinase activity (promoting cell death).