Meanwhile, amongst non-diabetic patients, either PNPLA3 rs738409 or TM6SF2 rs58542926 or in combination were not associated to the risk of advanced liver fibrosis, whereas age and HOMAR-IR, as biomarker of hepatic IR, were indeed risk factors of advanced fibrosis in the absence of T2D diagnosis. This evidence concerns the gene PNPLA3 and type 2 diabetes mellitus.