When T2D was combined with each of the two polymorphisms (G allele in PNPLA3 p.I148M variant or T allele in TM6SF2 p.E167K variant), the OR significantly increased (OR = 14.69; 95%CI 3.03–77.35; p = 0.001 and OR = 11.45; 95%CI 3.16–41.55; p < 0.001, respectively). This evidence concerns the gene PNPLA3 and type 2 diabetes mellitus.