Among the entire cohort, the risk factors associated with advanced liver fibrosis in the univariate analysis were age, T2D, HbA1c, the G allele for the PNPLA3 p.I148M variant, the presence of T allele for the TM6SF2 p.E167K variant, as well as the presence of either of two polymorphisms (G allele in PNPLA3 p.I148M variant and T allele in TM6SF2 p.E167K variant), as reflected in Table 4. This evidence concerns the gene PNPLA3 and Hepatic fibrosis.