Among them, single nucleotide polymorphism (SNP) rs738409 of the patatin-like phospholipase domain containing protein 3 (PNPLA3) gene [17,18] and SNP rs58542926 of the transmembrane protein involved in molecule transport (TM6SF2) gene [19] have been identified in several genome-wide association studies (GWAS) as risk factors for progressive NASH and advanced fibrosis [20]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.