The peculiar phenomenon observed in SVD is necroptosis, a different form of programmed cell death which, unlike apoptosis, does not involve caspase activation yet involves the loss of plasma membrane integrity through the receptor-interacting serine/threonine-protein kinase 1 (RIPK-1) and the mixed lineage kinase domain-like (MLKL) [85]. Here, RIPK1 is linked to snowflake vitreoretinal degeneration.