KDR rs52071559 and rs7671705, LDL receptor protein 5 (LPR5) rs3736228, frizzle class receptor 4 (FZD4) rs10898563, PLG2G12A rs2285714, hypoxia inducible factor 1 subunit α (HIF1A) rs11549465 and signal transducer and activator of transcription 3 (STAT3) rs744166 were studied by Smailhodzic and colleagues, but no correlation between the treatment and patient response was found in AMD patients [115]. The gene discussed is FZD4; the disease is age-related macular degeneration.