C3 and age-related macular degeneration: C3 rs2230199 [102,107] and CFB rs12614 [103] polymorphisms have been also tested in mouthwash samples of AMD patients, and no significant relationship has been found between these SNPs and the anti-VEGF response, although patients with the CT genotype of CFB rs12614 had a tendency to improve the VA after treatment [102,103].