Sakamoto et al. observed in a Japanese cohort of 48 AMD patients that many cytokines (C-X-C motif chemokine 1 (CXCL1), CXCL12, CXCL13, Monocyte chemoattractant protein 1 (MCP-1), C-C motif chemokine ligand 11 (CCL11), IL-6 and IL-10) were downregulated after two ranibizumab injections, while only MMP9 was increased after treatment [150]. This evidence concerns the gene CCL11 and age-related macular degeneration.