VEGFA and age-related macular degeneration: In this review, we discuss the great controversy between genetic, proteomic and metabolomic studies carried out in AMD ranibizumab-treated patients, and we propose that genomic, proteomic and/or metabolomic markers could be used not alone but in combination with other methods, such as specific clinic characteristics, to identify patients with a poor response to anti-VEGF treatment to establish patient-specific treatment plans.