Mouallem-Beziere et al. compared 300 neovascular AMD patients, with 68 resistant to ranibizumab therapy, that the GG genotype of C3 SNP rs2230199 was significantly associated with the phenotype of large vascularized pigment epithelial detachment poorly responding to anti-vascular endothelial growth factor therapy [139]. The gene discussed is VEGFA; the disease is age-related macular degeneration.