CRP and Abnormal renal physiology: Recently, Mizukawa et al. [17] created a composite score for evaluating DReSS severity based on a variety of factors including age, allopurinol-exposure, the need for pulsed prednisone, the duration of drug exposure after symptom onset, fever duration, % BSA, appetite loss, liver involvement, renal dysfunction, and C-reactive protein (CRP).