Indeed, the deposition of metabolically dynamic visceral adipose tissue in T2DM is thought to play a critical role in the secretion of common pro-inflammatory adipokines such as tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1, leptin, interleukin (IL-6), resistin, and plasminogen activator inhibitor-1 (PAI-1) [7,8]. The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.