On the other hand, in the presence of steatosis, the abolishment of NRG1 or PAK1 effects affected IGF1 since in steatotic livers from the BD+anti-NRG1+LT and BD+anti-PAK1+LT groups, IGF1 levels were lower than in the BD+LT group. The gene discussed is PAK1; the disease is Behcet disease.