It has been evidenced that NRG1 exerts important metabolic effects in the liver since NRG1 improves insulin resistance in rats by activating ErbB3 and promoting the phosphorylation of AKT in hepatocytes [10], which leads to suppression of gluconeogenic gene expression and hepatic glucose output, in both lean and obese mouse livers [9]. This evidence concerns the gene NRG1 and Insulin resistance.