Since these results reflecting exacerbated injury and regenerative failure in the BD+anti-NRG1+LT and BD+anti-PAK1+LT groups were associated with decreased VGFA and IGF1 in non-steatotic and steatotic livers, respectively, we then investigated whether endogenous NRG1-PAK1 exerted its benefits through VEGFA/IGF1. This evidence concerns the gene IGF1 and Behcet disease.