NRG1 and intracranial hypertension: Therefore, in our experimental model of BD and considering that both conditions are present (intracranial hypertension and cerebral ischemia) [50,51], it is possible that an increase in the expression of NRG1 in the brain also occurs, as reflected in the high levels of NRG1 in the systemic circulation, and consequently in an increase in the hepatic levels of NRG1 as observed in our results.