AKT1 and glioblastoma: Strikingly, silencing of HNRNPC lowered mi-R-21 levels in turn increased the expression of programmed cell death 4 (PDCD4), suppressing AKT serine/threonine kinase (Akt) and Ribosomal protein S6 kinase beta-1 (p70S6K) activation and inhibiting migration and invasion in glioblastoma [40].