FOXO3 plays a tumor-suppressor role in differentiated thyroid cancers where its expression is downregulated [54]; notably, FOXOs seem to promote the antitumor immune response by negatively regulating several immunosuppressive factors (e.g., PD-L1 and VEGF) and positively regulating chemokine attractants [55]. Here, CD274 is linked to thyroid gland carcinoma.