Given the crucial role of RISP-mediated ROS generation in COPD PASMCs and the large role that ROS generation plays on oxidative stress-induced DNA damage, examining the specific role of RISP-mediated DNA damage on PA vasoremodeling in COPD and PH may be a likely important avenue to develop future effective therapeutics. This evidence concerns the gene UQCRFS1 and chronic obstructive pulmonary disease.