In our study, cancer prevalence in the indeterminate cytology category was 24.4%; in the AUS/FLUS group of patients, 10 out of 11 were correctly detected with molecular testing, and malignancy was confirmed, while in contrast, 6 out of 35 patients underwent thyroid surgery for the reason of positive molecular testing with benign histology (4× RAS, 2× PTEN). Here, PTEN is linked to cancer.