CX3CL1 and Cognitive impairment: As shown in Figure 4, AUD patients with cognitive impairment displayed strong positive and significant correlations between VEGFA with all chemokines [SDF-1 (rho = 0.787, p < 0.001), eotaxin (rho = 0.678, p < 0.001), MIP-1α (rho = 0.592, p = 0.001), MCP-1 (rho = 0.601, p = 0.001), fractalkine (rho = 0.706, p < 0.001)], while we only observed a positive and significant correlation between VEGFA and SFD-1 (rho = 0.532, p = 0.009) for AUD patients without cognitive impairment (Table S4).