The morphological similarity of SLO pores and PNC-27-HDM2 pore complexes, together with the fatal outcome for cells whose plasma membranes have been penetrated and made leaky by the insertion of SLO pores, suggests a similar functional consequence to the formation of PNC-27-HDM-2 pore complexes as the cause of rapid cancer cell necrosis induced by PNC-27. Here, MDM2 is linked to cancer.