PNC-27 Induces Transmembrane Pores in Cancer Cells that Contain PNC-27-HDM-2 Complexes. The results shown in Figure 2, Figure 3, Figure 4 and Figure 5 suggest that PNC-27 induces the formation of transmembrane pores lined at the outer membrane surface with PNC-27-HDM-2 complexes. The gene discussed is MDM2; the disease is cancer.