This correlation of glomerular Panx1 expression with the severity of renal damage could also be explained by the conclusions of the study mentioned earlier, according to which the physiological tonic inhibition of Panx1 channel activity may be attenuated under pathological conditions—for example, in obesity due to hypoadiponectinemia [8]. Here, PANX1 is linked to obesity due to melanocortin 4 receptor deficiency.