Eczema cases (n = 498, mean age 10.5 years) more frequently 25(OH)D levels < 25 nmol/L than controls (n = 328, mean age 12.3 years) (mean 25(OH)D level (SD); 28.9 (15.3) vs. 34.2 nmol/L (14.5); p < 0.001) Total IgE and sensitization to aeroallergens (sIgE and SPT): not significant between groups. This evidence concerns the gene IGHE and Eczematoid dermatitis.