Therefore, decreased glucocorticoid levels are associated with increased oxidative stress, inflammation, adrenal insufficiency, altered metabolism of glucocorticoid metabolizing enzymes, decreased brain MAO-A activity, increased noradrenaline, downregulation of prefrontal cortex, amygdala hyperactivation, increased density of the tissue glucocorticoid receptors, upregulation of the corticotrophin releasing factor (CRH), blunted ACTH response to CRH stimulation, and blunted adrenal response to ACTH stimulation [77]. This evidence concerns the gene CRH and Adrenal insufficiency.