In contrast to our data, patients with generalized anxiety disorder or major depression had similar platelet MAO-B activity, and there was no correlation between platelet MAO-B and clinical severity of anxiety, determined using the Hamilton anxiety rating scale [66], and depression, panic disorder, or social phobia was not associated with platelet MAO-B activity in a large Australian sample, when controlled for the effect of smoking [50]. The gene discussed is MAOB; the disease is generalized anxiety disorder.